Integrated neurodegenerative disease autopsy diagnosis

Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer's Coordinating Centre.

Cerebrovascular disease and vascular risk factors are associated with Alzheimer's disease, but the evidence for their association with other neurodegenerative disorders is limited. Therefore, we compared the prevalence of cerebrovascular disease, vascular pathology and vascular risk factors in a wide range of neurodegenerative diseases and correlate them with dementia severity. Presence of cere...

Autopsy Diagnosis and Technique

descriptions of traditional therapeutic devices which clutter most other textbooks of medicine are wisely omitted in favor of concise directions in the light of modern therapeusis. Where indicated, thoroughness is not sacrificed to brevity-as for example, in the section on treatment of diphtheria the technic of tracheal intubation is described in detail. This reviewer suspects that, with the gr...

The infantile-onset form of Pompe disease: an autopsy diagnosis

Pompe disease (PD) is a rare, inherited autosomal recessive metabolic disorder caused by the deficiency of the lysosomal acid alpha-glucosidase (GAA) enzyme described in 1932 by the Dutch pathologist Joannes Cassianus Pompe. The prevalence of PD ranges from 1:40,000 to 1:300,000 births and depends on geographic and ethnic factors. Clinical manifestations may vary from a rapidly progressive disa...

Keystroke Analytics for Non- Invasive Diagnosis of Neurodegenerative Disease

Multi-Phase Feature Representation Learning for Neurodegenerative Disease Diagnosis

Feature learning with high dimensional neuroimaging features has been explored for the applications on neurodegenerative diseases. Low-dimensional biomarkers, such as mental status test scores, gene variations, and protein changes in plasma and cerebrospinal fluid level, are essential in clinical diagnosis of neurological disorders, because they could be simple and effective for the clinicians ...